![]() ![]() Causes can include brain tumors and sudden withdrawal from long-term exogenous steroid use (which is the most common cause overall).Ĭortisol is important for life and its production by the adrenal glands is especially important at times when the body experiences intense ‘stress’, such as surgery, trauma or serious infection. Tertiary adrenal insufficiency is due to hypothalamic disease and a decrease in the release of corticotropin releasing hormone (CRH).Secondary adrenal insufficiency is caused by impairment of the pituitary gland or hypothalamus. Its principal causes include pituitary adenoma (which can suppress production of adrenocorticotropic hormone (ACTH) and lead to adrenal deficiency unless the endogenous hormones are replaced) and Sheehan’s syndrome, which is associated with impairment of only the pituitary gland. ![]() ![]() Other cases are due to congenital adrenal hyperplasia or an adenoma (tumor) of the adrenal gland.One subtype is called idiopathic, meaning of unknown cause.80% are due to an autoimmune disease called Addison’s disease or autoimmune adrenolytic.Primary adrenal insufficiency is due to impairment of the adrenal glands.There are three major types of adrenal insufficiency.
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